Promising novel result from a so-and-so study suggest that an effective stem cell therapy for patients with Parkinson ’s disease could be within our grasp . After inject brain cell derived from human stem cells into rats with modelling of the condition , the rodent ’ ability to control movement was restored . Furthermore , after examining their brains , they find that the cell brought dopamine levels back to normal . While more work need to be done , the study brings scientist one tone nigher to the use of stem cell transplants in human trials . The study has been published inCell Stem Cell .
Parkinson ’s diseaseis a degenerative circumstance in which Intropin - producing cells in part of the Einstein are progressively damaged and lost over time . This causes a gradual decline in sleight and the power to check the amphetamine of movement . While there is no cure , therapies such as drugs and brain stimulation can reduce symptoms , but their effectiveness ebbing over time .
A different handling approach , which involve transplanting brainpower tissue paper from fetal cells , was trialed fairly recently , but it had mixed result . Some patient role hadlong - go benefits , but some experienced involuntary movements which were drive by the graft . The use of foetal cell also hasethical retainer , and supplies are scarce .
But there could be a dissimilar agency to replace the damaged tissue in patients ’ psyche : stem cell . Before they can be used in humans , however , researchers require to check that that they survive and functionally integrate into the brain of animals . To retrieve this out , researchers fromLund Universitytook dopamine neurons ( brain cell ) derive from human embryonic stem cell and injected them into git with a model of Parkinson ’s disease .
Not only did the cells display long - full term survival in the gnawer ’ brains , they also take Dopastat story back to normal in justfive month . Furthermore , the cells established long distance connections with other brain region , and communicated with thecorrect target areas . These crucial outcomes allowed motor function ( the control of apparent motion ) to be regenerate in the animals with a similar potency to that find when human foetal neuron are transfer . This evoke that stem cells could be aviable alternativeto using fetal cells , which is authoritative generate the virtual and ethical effect surrounding these cubicle .
“ It ’s a huge breakthrough in the theater of operations [ and ] a stepping I. F. Stone towards clinical trials , ” said lead researcherMalin Parmar . Although it ’s still early days , the researchers believe that these trials could set out as early as 2017 .
[ ViaLund University , Cell Stem Cell , Cell PressandBBC News ]
